The 3rd International Conference on Biomedical Engineering and Biotechnology (iCBEB2014)
The Exhibition on Biotechnology and Equipment
September 25-28, 2014, Beijing, China
Keynote Speakers

Dr. Edward J. Ciaccio

Department of Medicine, Division of Cardiology, Columbia University, USA.


1. Software Algorithm and Hardware Design for Real-Time Implementation of New Spectral Estimator 


Frequency analysis is important to biomedical engineering for the quantitation of medical signals and images. However, the most commonly used methods, the Fourier transform and the Wavelet transform, are composed of bases which lack biophysical meaning. The standard Fourier basis consists of a series of sinusoids, which rarely if ever convey the shape of repetitive patterns present in biomedical data. Similarly, the mother wavelet used for Wavelet analysis is selected from a library of candidate mother wavelets that has been developed over the past two decades and have no known biophysical meaning. Neither the Fourier transform nor the Wavelet transform is conducive to real-time calculation. This is due to the complex nature of their implementation and the need for a recalculation of most or all steps on each successive iteration. However, implementation of a real-time system for frequency analysis would enable content evolution to be evaluated at the maximum time resolution, i.e., every sample point.More...

2. Model of Bipolar Electrogram Fractionation and Conduction Block Associated with Activation Wavefront Direction at Infarct Border Zone Lateral Isthmus Boundaries


After myocardial infarction, an infarct border zone (IBZ) forms around the infarct region. The IBZ is an arrhythmogenic area where the electrical activation impulse slows and can travel along circuitous pathways. Ventricular tachycardia (VT) is a common heart arrhythmia, and is often caused by a double-loop reentrant circuit, in which two activation wavefronts propagate simultaneously around a common isthmus in the IBZ. It is possible to interrupt the circuit using radiofrequency catheter ablation during electrophysiologic study. However, correct targeting may be difficult due to the problem of identifying all arrhythmogenic regions responsible for the clinical tachycardias that occur in a particular patient, and because of hemodynamic compromise during VT, which precludes mapping of the heart surface. We have developed a method that can potentially be useful to detect arrhythmogenic regions from which VT can form, without the need for tachycardia induction or extensive electrophysiologic mapping.More...

Prof. Dan Barouch

Division of Vaccine Research, Department of Medicine, Harvard Medical School, Harvard University, USA.


Novel Vaccination and Therapeutic Strategies for HIV

Dr. Ng Yin Kwee

Division of Thermal and Fluids Engineering, School of Mechanical & Aerospace  Engineering, College of Engineering, Nanyang Technological University, SG.


Quantitative Means for Differentiating Kidney Obstruction by modelling Renography Data and derivation of Novel Renal Index of Urine Flow rate


The kidney has a main role in the blood filtration process to get rid of waste materials and maintain homeostatic functions, such as regulation of electrolytes, maintenance of acid-base balance and regulation of blood pressure. Renography is a kidney imaging technique used to detect renal health status. However for the purpose of diagnosis renal obstruction, there is still no precise technique and standard protocol accepted and applied in the clinical setting. This research example was carried out to search for a non-invasive method in the assessment of renal obstruction and to come out with a benchmark for clinical evaluation of the severity of obstructed kidney. More...

Prof. Christopher R. Jacobs

Department of Biomedical Engineering, Columbia University, USA.


Integrative cellular mechanobiology and biomechanics and the emergence of primary cilia as mechanosensors


Cellular mechanosensation is critical in diseases responsible for enormous human suffering including atherosclerosis, osteoarthritis, cancer, and osteoporosis. Nonetheless, very little is understood about the molecular mechanisms of mechanotransduction outside of a small number of specialized sensory cells. Primary cilia are solitary linear cellular extensions that extend from the surface of virtually all cells. For decades, the biologic function of these enigmatic structures was elusive, however, recent evidence suggests an emerging picture in which the primary cilium functions as a complex nexus where both physical and chemical extracellular signals are sensed and responses coordinated.More...

Prof. Sudhir Gupta

Professor of Medicine, Pathology & Laboratory Medicine, and Microbiology & Molecular Genetics, and the Chief of the Division of Basic and Clinical Immunology, University of California, USA.


Paradox of Immunosenescence and inflammation & Autoimmunity: Role of Dendritic Cells


Aging is associated with a progressive decline in T cell function, chronic inflammation, autoimmunity, poor response to vaccines, and increased susceptibility to infection as well as diseases associated with chronic inflammation. Both thymic involution and increased apoptosis of T cell subsets appear to contribute to T cell immunosenescence. Dendritic cells (DCs) in aging appears to be functionally impaired with regard to response to uptake of antigens, phagocytosis of apoptotic cells, migration, priming of CD4+ and CD8+ T cells, and production of IFN-I and IFN-III, which contribute to chronic inflammation and autoimmunity in aging. In this presentation, I will discuss the molecular mechanisms of increased cell death in naïve and central memory T cells, and signaling mechanisms and epigenetic changes in DCs that contribute to chronic inflammation, autoimmunity, impaired T cell functions, poor response to vaccines, and increased susceptibility to infections in human aging.

Prof. Alain-Li Wan Po

Director of the Centre for Evidence-Based Pharmacotherapy, Nottingham, UK.


Genomics and the transformation of the clinical, chemical and pharmaceutical sciences.


Genomics can be defined as the use of molecular methods to interrogate the genome, the complete genetic make-up of a cell, individual or population (meta-genome). Over recent years, genomic insights have led to major progress in the clinical, chemical and pharmaceutical sciences that is reminiscent of the revolutionary progress made in those sciences at the end of the 18th century, accelerating over the first half of the last century and culminating in the establishment of the double-helical structure of DNA.More...

Dr.Pawan K. Agrawal

Natural Product Inc., Westerville, Ohio, USA.


Carbon-13 NMR Chemical Shift of OMe Group: Structural Significance for Methoxylated Aromatic Compounds


Phenolic substances, such as flavonoids, coumarins, lignans and cinnamic acids, isolated from a variety of plants, including fruits and vegetables. In many such substances, some of the phenolic hydroxyl groups are substituted, and O-methylation is often observed. The 13C NMR spectra of these compounds reflect that the chemical shift range 55-62 ppm is characteristic for OMe signals. The significance of OMe chemical shift in elucidating structures of phenolic compounds will be presented.

Prof. Anil K. Mandal

Department of Medicine, University of Florida, USA.


Control of delta (d) glucose with intensive insulin therapy is fundamental to renal preservation in diabetes.


This presentation encompasses background information on no attention to glycemic control with sparse use of insulin therapy, but on the contrary more interest in controlling microalbuminuria with excessive use of angiotensin converting enzyme inhibitor (ACEI) and or angiotensin receptor blocker (ARB) drugs.
The results are high incidence of acute renal failure associated with cumulative high risk of end stage renal disease (ESRD) and dialysis. Steps are taken by the author to reveal that glycemic control with insulin therapy and complete exclusion of ACEI/ARB drugs are fundamental to renal preservation in diabetes.Prior to testing this hypothesis basic research was done to examine the response of vascular endothelial cells (ECS) to high glucose (30mmol or 540mg) environment for 2, 6 or 10 days. More...

Prof. Rui Fausto

Department of Chemistry, Faculty of Sciences and Technology of the University of Coimbra, Portugal.


The Potential Energy Landscapes of Biologically Relevant Molecules Revealed by Matrix-Isolation Infrared Spectroscopy and Quantum Chemical Calculations


The importance of molecular conformations in biochemistry (as in chemistry and physics) is well accepted. The conformations assumed by the molecules and their associated potential energy landscapes determine, for instance, catalytic mechanisms in enzymes, antifreeze cryoprotectants efficiency or membrane properties, and are the basis of the general phenomenon of molecular recognition. Conformational changes are key events in the vision process, in the control of membrane permeability and different mechanism of molecular transport in cells. Protein folding is controlled by conformations of the constituting amino acids, and the preferred spatial arrangements of the nucleic acid bases are also essential in determining the functioning of these later.More...

More will be coming soon...

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